Sveinsson chorioretinal atrophy: the mildest changes are located in the photoreceptor outer segment/retinal pigment epithelium junction
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چکیده
منابع مشابه
Morphological changes in injured retinal pigment epithelium and photoreceptor cells after transplantation of stem cells into subretinal space
Introduction: Degenerative retinal diseases are main cause of irreversible blindness. Stem cells therapy is a promising way in these diseases. Therefore, mesenchymal stem cells because of its safety can produce degenerated cells and can play important role in treatment. The aim of this study was to examine morphological changes in injured retinal pigment epithelium (RPE) and photoreceptor cells...
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PURPOSE Recent studies have shown that A2 adenosine receptors are present in retinal pigment epithelium (RPE). In this study, the effect of adenosine and adenosine analogues on photoreceptor outer segment (ROS) phagocytosis by RPE was investigated. METHODS Primary cultures of RPE cells were incubated with isolated outer segments in the presence of various adenosine derivatives. Changes in ade...
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Mutations in genes expressed in the retinal pigment epithelium (RPE) underlie a number of human inherited retinal disorders that manifest with photoreceptor degeneration. Because light-evoked responses of the RPE are generated secondary to rod photoreceptor activity, RPE response reductions observed in human patients or animal models may simply reflect decreased photoreceptor input. The purpose...
متن کاملIntegrin alphavbeta5 participates in the binding of photoreceptor rod outer segments during phagocytosis by cultured human retinal pigment epithelium.
PURPOSE To examine the expression of integrin vitronectin receptors (integrins alphavbeta3 and alphavbeta5) in native human fetal retinal pigment epithelium (RPE) and cultured hunman fetal RPE and to examine the role of RPE VnRs in the phagocytosis of photoreceptor rod outer segments (ROS). METHODS Monoclonal antibodies against human integrin subunit alphav and heterodimers alphavbeta3 (LM609...
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ژورنال
عنوان ژورنال: Acta Ophthalmologica Scandinavica
سال: 2007
ISSN: 1395-3907
DOI: 10.1111/j.1600-0420.2007.01002.x